Two severe cases of Japanese encephalitis virus (JEV) were reported in French travelers returning from endemic regions between 2023-2024. Patients presented with neurological symptoms indicative of severe encephalitis. Diagnosis was confirmed through specific serological and molecular testing for JEV. These cases underscore the significant risk of JEV infection for unvaccinated travelers to endemic areas, highlighting the critical need for pre-travel vaccination and robust personal protective measures against mosquito bites. The severity of these infections emphasizes the importance of early diagnosis and public health awareness for returning travelers.
Key note: Japanese encephalitis vaccination and mosquito bite prevention are crucial for travelers to endemic regions.