Microbiological treatment failure associated with macrolide-resistant Bordetella pertussis

March 11, 2025
Clinical Microbiology
David Prabhakar, Winkie Fong, Eby M Sim, Annaleise R Howard-Jones, Trang Nguyen, Suzanne Dempsey, Rebecca J Rockett, Jen Kok, Sharon C-A Chen, Alexander C Outhred, Vitali Sintchenko
Pathogen:Bordetella pertussis
Infection Type:Respiratory infection
Pathogen Type:Bacteria

Summary

A clinical case reports microbiological treatment failure in a patient with pertussis caused by macrolide-resistant Bordetella pertussis (MRBP). The patient's demographics and initial symptoms are not detailed, but the focus is on the challenge of treating this emerging resistant strain. Diagnosis involved identifying B. pertussis, followed by confirmation of macrolide resistance. This case highlights the increasing prevalence of MRBP, which complicates standard treatment protocols and necessitates vigilance for treatment failures. The report underscores the importance of ongoing surveillance and alternative therapeutic strategies for pertussis, especially in regions with rising resistance.

Key note: Macrolide resistance in Bordetella pertussis can lead to treatment failure, requiring alternative management strategies.

DOI: 10.1128/asmcr.00093-24