A patient undergoing CD19 chimeric antigen receptor T-cell (CAR-T) therapy developed invasive fusariosis, a rare but severe complication in immunocompromised individuals. The patient presented with a cutaneous lesion, which was subsequently biopsied and cultured, leading to the identification of Fusarium species. This case highlights the importance of considering opportunistic fungal infections, specifically Fusarium, in patients with profound immunosuppression following CAR-T therapy, even when presenting with seemingly localized skin lesions. Early diagnosis through biopsy and culture is crucial for timely and effective management in this vulnerable population.
Key note: Invasive fusariosis can manifest cutaneously in CAR-T recipients, necessitating vigilance and prompt diagnostic workup.