A patient presented with a Corynebacterium striatum osteoarticular infection, a challenging diagnosis due to its commensal nature and biofilm formation. Initial treatment involved daptomycin, but the pathogen rapidly acquired resistance, necessitating a change in therapy. This case highlights the critical issue of antimicrobial resistance development even during ongoing treatment, particularly with less common pathogens. The infection type was osteoarticular, and the organism was identified through standard microbiological methods. The rapid resistance acquisition to daptomycin underscores the need for vigilant monitoring and susceptibility testing in such infections.
Key note: Corynebacterium striatum can rapidly acquire daptomycin resistance during treatment, emphasizing the importance of continuous antimicrobial susceptibility monitoring.