Reactive infectious mucocutaneous eruption: an increasingly encountered complication during periods of increased Mycoplasma pneumoniae transmission—a case report

September 12, 2025
Case Report
Andrew E Clark, Lakshmi Marimuthu, Anna Sick-Samuels, Heba H Mostafa
Pathogen:Mycoplasma pneumoniae
Infection Type:Respiratory infection
Pathogen Type:Bacteria

Summary

A pediatric patient presented with reactive infectious mucocutaneous eruption (RIME), a severe mucocutaneous reaction, during a period of heightened Mycoplasma pneumoniae incidence. The diagnosis was confirmed through molecular testing, specifically PCR, which identified Mycoplasma pneumoniae as the causative pathogen. This case highlights the increasing recognition of RIME as a significant complication associated with Mycoplasma pneumoniae infections, especially during outbreaks. Clinicians should be aware of this severe manifestation and consider Mycoplasma pneumoniae in the differential diagnosis for patients presenting with RIME, facilitating timely diagnosis and appropriate management.

Key note: Mycoplasma pneumoniae should be considered a primary cause of RIME, particularly during periods of increased transmission.

DOI: 10.1128/asmcr.00107-25