A bilateral double-lung transplanted cystic fibrosis patient experienced acute rejection, likely complicated by a multidrug-resistant bacterial infection. The primary pathogen was identified as Pseudomonas aeruginosa. Traditional antimicrobial treatments were insufficient, leading to the implementation of phage therapy. Following phage intervention, the patient's acute rejection resolved, demonstrating the potential of bacteriophages as an alternative therapeutic strategy. This case highlights the efficacy of phage therapy in managing complex infections in immunocompromised patients, particularly when conventional antibiotics fail, and its unexpected positive impact on transplant rejection.
Key note: Phage therapy can resolve acute rejection in lung transplant patients by effectively treating underlying multidrug-resistant bacterial infections.