A 21-year-old pregnant cisgender woman, HIV-positive, presented with disseminated cryptococcosis, including cryptococcal meningitis and fungemia. Initial treatment with liposomal amphotericin B was complicated by an acute infusion reaction, prompting a successful desensitization protocol. The patient tolerated subsequent doses without further reactions, allowing for effective management of the severe fungal infection during pregnancy. She delivered a healthy infant, and both mother and child remained well post-treatment. This case highlights the critical importance of desensitization protocols for essential medications in vulnerable populations when adverse reactions occur.
Key note: Successful desensitization to liposomal amphotericin B is feasible and crucial for managing severe infections in pregnant patients with drug hypersensitivity.