A patient presented with a refractory, extensively drug-resistant (XDR) Pseudomonas osteomyelitis and hardware infection, likely following a traumatic injury and subsequent surgical intervention. The infection was caused by a hypermutator strain of Pseudomonas aeruginosa, identified through culture and genomic sequencing. Standard antibiotic therapies were ineffective due to the pathogen's resistance profile. Adjunctive bacteriophage therapy was administered, leading to successful clearance of the infection and preservation of the hardware. This case highlights the potential of phage therapy for complex, multidrug-resistant bacterial infections where conventional treatments fail.
Key note: Bacteriophage therapy can be a crucial adjunctive treatment for otherwise untreatable XDR bacterial infections, especially those involving hardware.